Metagenics Ultra Flora GI SootheSpecialised probiotic to reduce the occurrence and symptoms associated with medically diagnosed IBS.Ingredients in Ultra Flora GI Soothe have been clinically shown to, or may help to:Assist in the management of medically diagnosed irritable bowel syndrome (IBS).Reduce occurrence of IBS symptoms including, gastrointestinal pain, discomfort, bloating and excessive gas.Contains clinically proven, extensively researched exclusive probiotic strain Lactobacillus plantarum 299v. Ingredients and their functionsLactobacillus plantarum 299v 20 billion CFU per capL. plantarum 299v is an extensively researched probiotic strain having been investigated in at least 140 studies to date, with more than 50 clinical trials. DirectionsAdults: Take 1 to 2 capsules daily. Store at 2° to 8° (Refrigerate. Do not freeze.) If symptoms persist, see your healthcare provider. Clinical BenefitsAround 1 in 5 people experience the unpleasant symptoms of IBS at some stage including abdominal pain, mucous in stools, and diarrhoea. L. plantarum 299v is an extensively researched probiotic strain having been investigated in at least 140 studies to date, with more than 50 clinical trials. Irritable Bowel SyndromeA randomised, double-blind placebo-controlled trial tested the efficacy of L. plantarum 299v in 40 people with IBS over four weeks.All patients treated with L. plantarum 299v reported significant improvement in stool frequency and complete resolution of their abdominal painAn overall improvement in all IBS symptoms were noted in 95% of patients in the treatment group, compared to only 15% in the placebo group (Figure 2). Another study involving 204 adults with medically diagnosed IBS found significant symptom improvement within 2 to 4 weeks including abdominal bloating, pain and bowel movements.A 12-week RCT published in 2021 showed 299v alleviated IBS symptoms of abdominal pain, flatulence, bloating, constipation, as well as improving the feeling of incomplete/urgent evacuation by 50% after 4 weeks and decreased diarrhoea severity and frequency.299v’s significant and continuous reduction of overall symptom scores observed is compelling for IBS sufferers. Further, long-term treatment with 299v was well tolerated by 94% of the patients and quality of life increased, encompassing mental wellbeing and influence on everyday life. Defective mucosal intolerance and inflammationDisruption of the intestinal barrier can lead to inappropriate inflammatory responses which may occur in IBS.Studies have shown L.plantarum299v to have an effect on barrier function by decrease in permeability L. plantarum 299v has also been shown to exert antipathogenic activity via the production of antimicrobial compounds and inhibiting pathogen adhesion.StressA randomised control trial shows L. plantarum 299v reduces salivary cortisol during stress. Stress is well recognised as a common trigger for IBS impacting gut secretions, motility, sensitivity and intestinal permeability.A 2016 study on 41 students showed a significant difference in salivary cortisol levels after only 10 days of taking 10 billion CFU. ReferencesNiedzielin K, Kordecki, H and Birkenfeld, B. A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299v in patients with Irritable Bowel Syndrome. Eur J Gastro Hepat 2001; 13:1143-7
